As a neuromuscular specialist and electrophysiologist, I have experience with the diagnostic and treatment
aspects of a variety of nerve disorders. I have also completed a designated clinical research fellowship in
inherited neuropathy, during which I learned about outcome measures and clinical trial design strategies
specific to diseases of nerve. My research to date has focused on optimizing outcome measures for slowly
progressive neuropathies with the goal of carrying out effective treatment trials. I have conducted a natural
history study of inherited neuropathy in the largest patient cohort reported to date and have presented
longitudinal data from this patient population at the Peripheral Nerve Society. I have also developed specific expertise in Hereditary Sensory Autonomic Neuropathy Type I (HSAN1) and have carried out a biomarker study and a randomized controlled trial in HSAN1 in collaboration with Dr. Florian Eichler at Massachusetts General Hospital. HSAN1 and diabetic neuropathy are phenotypically similar and appear to share a pathomechanism. Having gained expertise in HSAN1, I am therefore well poised to carry out the proposed clinical trial evaluating lipid profiles in diabetic neuropathy before and after L-serine supplementation. The clinical trial design and selection of outcome measures in this trial have been informed and strengthened by my experience with HSAN1. I am fortunate in being able to carry out this work in collaboration with Dr. Simona Zarini in the laboratory of Dr. Robert Murphy at the University of Colorado, which is a world premier laboratory in the study of lipid biology and mass spectrometry. Finally, the mentorship of Dr. Jane Reusch, who has extensive experience in clinical and translational trials addressing the complications of diabetes, will be instrumental in the clinical trial design of the proposed study and in my transition to becoming an independent neuropathy researcher.