Postdoctoral Fellow/Basic Research in Peripheral Neuropathy

Description: Current opening for a postdoctoral fellow to investigate mechanisms of acquired and genetic peripheral neuropathies. Potential projects include developing a rodent model of autoimmune small-fiber polyneuropathy using sera from appropriate patients and/or working with mouse models of the hereditary sensory autonomic neuropathies (HSAN1 and HSAN3). The fellowship is sponsored by funded research grants from the NIH and DoD, although fellows are expected to gain experience by also applying for postdoctoral fellowship grants.

Location: The Nerve Unit is a clinical and research group within the Department of Neurology of the Massachusetts General Hospital in Boston. The director, A.L. Oaklander, MD PhD, is a peripheral nerve specialist with broad interests in diseases that affect the small-fiber peripheral neurons.

Applicants: Candidates should have an advanced degree in medical research in a relevant subject such as neuroscience, genetics, or immunology. Applicants must demonstrate English-speaking fluency.

Salary commensurate with NIH and hospital guidelines.

Qualified applicants should email a single PDF file including a letter describing their career goals and availability, CV, and contact information of three references to aloaklander@mgh.harvard.edu.

Relevant publications from the Oaklander lab:

Friedman V, Novak P, David W, Oaklander AL, Macklin E, McKenna-Yasek D, Walsh K, Brown R, Hornemann T, Eichler F. A randomized, double-blind, placebo-controlled, delayed-start trial to evaluate the safety and efficacy of L-serine in subjects with hereditary sensory and autonomic neuropathy type 1 (HSAN1). Annals of Neurology. 2016; 80:S243.

Liu X, Treister R, Lang M, Oaklander AL. IVIg for apparently autoimmune small-fiber polyneuropathy: First analysis of efficacy and safety. Therapeutic Advances in Neurological Disorders 2017; in press.

Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I. Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia. Hum Mol Genet 2016;25(6):1116-1128.

Lang M, Treister R, Oaklander AL. Diagnostic value of blood tests for occult causes of initially idiopathic small-fiber polyneuropathy. J Neurol 2016;263(12):2515-2527.

Liu Y, Magro C, Loewenstein JI, Makar RS, Stowell CP, Dzik WH, Hochberg EP, Oaklander AL, Sobrin L. A man with paraneoplastic retinopathy plus small fiber polyneuropathy associated with Waldenström macroglobulinemia (lymphoplasmacytic lymphoma): Insights into mechanisms. Ocul Immunol Inflamm 2015;23(5):405-409.

Oaklander AL, Klein MM. Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes. Pediatrics 2013;131(4):e1091-e1100.