Adults and children with neuropathic pain disorders of unknown cause are being recruited for clinical and genetic studies ("Sodium channel-related pain disorders: From molecular mechanisms towards personalized treatment")
Following her medicine studies at the RWTH Aachen University (2008-2014), Maike F. Dohrn has received a five-year training in general neurology at the University Hospital in Aachen, Germany. Since 2011, she has developed a clinical and scientific focus on rare neuromuscular diseases at the neuromuscular center Aachen, added by research internships at the Center of Genomics and Transcriptomics (CeGaT) in Tübingen, Germany, in 2016 and at the Corino Andrade Unit of the University of Porto, Portugal, in 2017. She has been conducting studies on Charcot-Marie-Tooth disease, hereditary sensory and autonomic neuropathies, transthyretin-related hereditary amyloidosis, small fiber neuropathies, inflammatory neuropathies, and motor neuron diseases, and became an expert in neuromuscular genetics, neurophysiology, and nerve ultrasound. As a co-investigator, she participated in the German CMT registry, the national CMT-NET, the international THAOS registry, and further multicenter trials. In the new Sodium channel network Aachen (SCNAC), she is the principal investigator for the clinical sub-project (Z-project). Despite being one of the youngest researchers in this field, she has already received fundings and scholarships from organizations including IZKF, ASPIRE, and DFG and won several awards (RADIZ rare disease award, Borchers badge, and Springorium coin) for her work. Currently, she is a research scholar at Professor Stephan Züchner's group at the John P. Hussman Institute for Human Genomics at the University of Miami.
Frequent genes in rare diseases: panel-based next generation sequencing to disclose causal mutations in hereditary neuropathies.
Dohrn MF, Glöckle N, Mulahasanovic L, Heller C, Mohr J, Bauer C, Riesch E, Becker A, Battke F, Hörtnagel K, Hornemann T, Suriyanarayanan S, Blankenburg M, Schulz JB, Claeys KG, Gess B, Katona I, Ferbert A, Vittore D, Grimm A, Wolking S, Schöls L, Lerche H, Korenke GC, Fischer D, Schrank B, Kotzaeridou U, Kurlemann G, Dräger B, Schirmacher A, Young P, Schlotter-Weigel B, Biskup S. J.
Neurochem. 2017 Dec;143(5):507-522. doi: 10.1111/jnc.14217. Epub 2017 Nov 7.
Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy.
Dohrn MF, Röcken C, De Bleecker JL, Martin JJ, Vorgerd M, Van den Bergh PY, Ferbert A, Hinderhofer K, Schröder JM, Weis J, Schulz JB, Claeys KG.
J Neurol. 2013 Dec;260(12):3093-108.
[Neuropathic pain syndromes and channelopathies].
Dohrn MF, Lampert A, Üçeyler N, Kurth I.
Internist (Berl). 2019 Jan;60(1):90-97.
Does APC/CCDH1 control the human brain size?: An Editorial Highlight for 'A novel human Cdh1 mutation impairs anaphase-promoting complex/cyclosome (APC/C) activity resulting in microcephaly, psychomotor retardation, and epilepsy' on page 103.
Dohrn MF, Bolaños JP.
J Neurochem. 2019 Oct;151(1):8-10.
Metabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP).
Hube L, Dohrn MF, Karsai G, Hirshman S, Van Damme P, Schulz JB, Weis J, Hornemann T, Claeys KG.
PLoS One. 2017 Jan 23;12(1):e0170583.
Chance or challenge, spoilt for choice? New recommendations on diagnostic and therapeutic considerations in hereditary transthyretin amyloidosis with polyneuropathy: the German/Austrian position and review of the literature.
Dohrn MF, Auer-Grumbach M, Baron R, Birklein F, Escolano-Lozano F, Geber C, Grether N, Hagenacker T, Hund E, Sachau J, Schilling M, Schmidt J, Schulte-Mattler W, Sommer C, Weiler M, Wunderlich G, Hahn K.
J Neurol. 2020 Jun 4.
Semi-automated volumetry of MRI serves as a biomarker in neuromuscular patients.
Müller M, Dohrn MF, Romanzetti S, Gadermayr M, Reetz K, Krämer NA, Kuhl C, Schulz JB, Gess B.
Muscle Nerve. 2020 May;61(5):600-607.
Role of high-resolution ultrasound in detection and monitoring of peripheral nerve tumor burden in neurofibromatosis in children.
Winter N, Dohrn MF, Wittlinger J, Loizides A, Gruber H, Grimm A.<
Childs Nerv Syst. 2020 Jun 19.
Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?
Dohrn MF, Othman A, Hirshman SK, Bode H, Alecu I, Fähndrich E, Karges W, Weis J, Schulz JB, Hornemann T, Claeys KG.
Eur J Neurol. 2015 May;22(5):806-14, e55.